Nanocrystalline MgAl2O4 as a Heterogeneous Nanocatalyst for the Synthesis of 2-Ketomethylquinolines Using Green Design Methodology

In this investigation, a facile and green sonochemical route has been developed for the synthesis of 2-Ketomethylquinolines by using 2-methylquinolines and several acyl chlorides in the presence of nanocrystalline MgAl2O4 as an efficient heterogeneous catalyst. The combination of nanocatalyst and ultrasonic process afforded corresponding ketomethyl quinolines in shorter reaction durations, and in high yields. This work consistently has the advantages of excellent yields, short reaction time, mild condition and work-up procedures. This method might be useful in the future for the preparation of similar derivatives.